The Drosophila Formin Daam Regulates the Tracheal Cuticle Pattern Through Organizing the Actin Cytoskeleton.
From: Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, H-6726 Szeged, Temesvári krt. 62, Hungary.
Development (Cambridge, England)
- Publish Date: Mar 2006
- ISSN: 0950-1991
- Volume: 133
- Issue: 5
- Pages: 957-66
- Medium: Print
- Language: English
- Citation (JAMA): Matusek Tamás, Djiane Alexandre, Jankovics Ferenc, et al. The Drosophila Formin Daam Regulates the Tracheal Cuticle Pattern Through Organizing the Actin Cytoskeleton.. Development Mar 2006;133:957-66
Abstract
Formins are involved in a wide range of cellular processes that require the remodeling of the actin cytoskeleton. Here, we have analyzed a novel Drosophila formin, belonging to the recently described DAAM subfamily. In contrast to previous assumptions, we show that DAAM plays no essential role in planar cell polarity signaling, but it has striking requirements in organizing apical actin cables that define the taenidial fold pattern of the tracheal cuticle. These observations provide evidence the first time that the function of the taenidial organization is to prevent the collapse of the tracheal tubes. Our results indicate that although DAAM is regulated by RhoA, it functions upstream or parallel to the non-receptor tyrosine kinases Src42A and Tec29 to organize the actin cytoskeleton and to determine the cuticle pattern of the Drosophila respiratory system.
Mesh Headings (Keywords): Actins, Adaptor Proteins, Signal Transducing, Animals, Body Patterning, Cytoskeleton, Drosophila, Drosophila Proteins, Mutation, Protein-Tyrosine Kinases, Proto-Oncogene Proteins pp60(c-src), Trachea, rho GTP-Binding Proteins
Check for Full Text / PubMed Unique Identifier (PMID): 16469972
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.