Responses of Brain and Non-brain Endothelial Cells to Meningitis-causing Escherichia Coli K1.
From: Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, 600 North Wolfe St., Park 256, Baltimore, MD 21287, USA. bacteriologist@mikrobe.org
Biochemical and biophysical research communications
- Publish Date: Mar 2006
- ISSN: 0006-291X
- Volume: 342
- Issue: 1
- Pages: 81-5
- Medium: Print
- Language: English
- Citation (JAMA): Paul-Satyaseela Maneesh, Xie Yi, Di Cello Francescopaolo, et al. Responses of Brain and Non-brain Endothelial Cells to Meningitis-causing Escherichia Coli K1.. Biochem. Biophys. Res. Commun. Mar 2006;342:81-5
Abstract
Bacterial interaction with specific host tissue may contribute to its propensity to cause an infection in a particular site. In this study, we examined whether meningitis-causing Escherichia coli K1 interaction with human brain microvascular endothelial cells, which constitute the blood-brain barrier, differed from its interaction with non-brain endothelial cells derived from skin and umbilical cord. We showed that E. coli K1 association was significantly greater with human brain microvascular endothelial cells than with non-brain endothelial cells. In addition, human brain microvascular endothelial cells maintained their morphology and intercellular junctional resistance in response to E. coli K1. In contrast, non-brain endothelial cells exhibited decreased transendothelial electrical resistance and detachment from the matrix upon exposure to E. coli K1. These different responses of brain and non-brain endothelial cells to E. coli K1 may form the basis of E. coli K1’s propensity to cause meningitis.
Mesh Headings (Keywords): Adhesins, Escherichia coli, Bacterial Toxins, Blood-Brain Barrier, Brain, Cells, Cultured, Electric Impedance, Endothelial Cells, Escherichia coli, Escherichia coli Proteins, Fimbriae Proteins, Humans, Mutation, Skin, Time Factors, Umbilical Cord
Check for Full Text / PubMed Unique Identifier (PMID): 16472773
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