Zaprinast Consolidates Long-term Memory when Administered to Neonate Chicks Trained Using a Weakly Reinforced Single Trial Passive Avoidance Task.
From: School of Psychology, Psychiatry and Psychological Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Wellington Rd., Clayton, Vic. 3800, Australia.
Behavioural brain research
- Publish Date: Apr 2006
- ISSN: 0166-4328
- Volume: 169
- Issue: 1
- Pages: 181-5
- Medium: Print
- Language: English
- Citation (JAMA): Campbell Emma, Edwards Thomas, et al. Zaprinast Consolidates Long-term Memory when Administered to Neonate Chicks Trained Using a Weakly Reinforced Single Trial Passive Avoidance Task.. Behav. Brain Res. Apr 2006;169:181-5
Abstract
A weakly reinforced variant of the single trial passive avoidance task developed for the day-old chick typically fails to consolidate long-term memory. However, administration of zaprinast, a phosphodiesterase (PDE) type 5 inhibitor, (ic; 10 microl/side) immediately post-training resulted in a dose-dependent increase in retention at test 180 min post-training. Further, 100 microM zaprinast resulted in high levels of retention at test 180 min post-training when administered from 10 min before training to 10 min after training. Finally, 100 microM zaprinast, when administered immediately post-training, resulted in the consolidation of long-term memory at a number of times of test extending as late as 24 h post-training. Inhibition of PDE type 5 is known to increase cellular cGMP levels. Previous investigations using a strongly reinforced variant of this task have suggested a role for cGMP in memory retrieval, we now postulate that cGMP is also necessary for memory formation in chicks trained using passive avoidance.
Mesh Headings (Keywords): 3’,5’-Cyclic-GMP Phosphodiesterases, Analysis of Variance, Animals, Avoidance Learning, Chickens, Dose-Response Relationship, Drug, Drug Administration Schedule, Nootropic Agents, Purinones, Reinforcement (Psychology), Retention (Psychology)
Check for Full Text / PubMed Unique Identifier (PMID): 16472878
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