Increase of Carotid Artery Stiffness and Decrease of Baroreflex Sensitivity in Exfoliation Syndrome and Glaucoma.
From: Department of Ophthalmology, Semmelweis University, Budapest, Hungary. hg@szem1.sote.hu
The British journal of ophthalmology
- Publish Date: May 2006
- ISSN: 0007-1161
- Volume: 90
- Issue: 5
- Pages: 563-7
- Medium: Print
- Language: English
- Citation (JAMA): Visontai Z, Merisch B, Kollai M, et al. Increase of Carotid Artery Stiffness and Decrease of Baroreflex Sensitivity in Exfoliation Syndrome and Glaucoma.. May 2006;90:563-7
Abstract
AIM: To investigate the distensibility of the common carotid artery (CCA), baroreflex sensitivity (BRS) and its relation to plasma homocysteine concentration in exfoliation syndrome or exfoliation glaucoma (XFS/XFG). METHODS: Homocysteine concentrations were measured in 30 XFS/XFG patients and 18 age matched controls. In 21 patients and 17 controls the end diastolic diameter of the CCA and pulsatile distension were measured and BRS was calculated. RESULTS: There was no significant difference between the groups in sex distribution, age, heart rate, blood pressure, systemic diseases, or medication. In XFS/XFG patients homocysteine concentration was significantly elevated (unpaired t test, p = 0.023), and CCA stiffness was higher (p<0.05), while strain, cross sectional compliance coefficient, distensibility, and BRS were significantly reduced compared to the controls (Mann-Whitney U test, p< or =0.013 for each parameter). In XFS/XFG patients a positive correlation was found between age and plasma homocysteine level (Pearson’s correlation, r = 0.490, p = 0.007), and a negative correlation between age and BRS (Kendall’s correlation r = -0.374, p = 0.021), as well as between homocysteine concentration and BRS (Kendall’s correlation r = -0.377, p = 0.024). No correlation was seen between these variables in the control group. CONCLUSIONS: These results suggest a pathological large artery function as well as altered parasympathetic vascular control in XFS/XFG which increases with age and with higher homocysteine concentration.
Mesh Headings (Keywords): Aged, Aged, 80 and over, Baroreflex, Blood Pressure, Carotid Artery, Common, Case-Control Studies, Chi-Square Distribution, Elasticity, Electrocardiography, Exfoliation Syndrome, Female, Glaucoma, Open-Angle, Humans, Hyperhomocysteinemia, Male, Middle Aged, Pulse, Tunica Intima
Check for Full Text / PubMed Unique Identifier (PMID): 16488931
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