Identifying Cancer Stem Cells in Solid Tumors: Case Not Proven.
From: Ontario Cancer Institute, Princess Margaret Hospital, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. hill@uhnres.utoronto.ca
Cancer research
- Publish Date: Feb 2006
- ISSN: 0008-5472
- Volume: 66
- Issue: 4
- Pages: 1891-5; discussion 1890
- Medium: Print
- Language: English
- Citation (JAMA): Hill Richard P, et al. Identifying Cancer Stem Cells in Solid Tumors: Case Not Proven.. Cancer Res. Feb 2006;66:1891-5; discussion 1890
Abstract
Building on studies of leukemia, a number of recent articles have reported data suggesting that cancer stem cells could be isolated from solid human cancers. Some of these reports have speculated that the isolation of these cells will allow the identification of the specific molecular properties that can be targeted for therapeutic purposes. Although previous work with animal model systems also suggests the presence of stem cells in solid tumors, there remain many uncertainties, both theoretical and technical, about the interpretation of the current results. The case that a small proportion of cells in solid tumors are specific cancer stem cells and that these cells can be successfully identified and isolated has not yet been proven.
Mesh Headings (Keywords): Animals, Humans, Neoplasms, Neoplastic Stem Cells
Check for Full Text / PubMed Unique Identifier (PMID): 16488984
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