Beneficial Effects of Alpha Linolenic Acid Rich Flaxseed Oil on Growth Performance and Hepatic Cholesterol Metabolism in High Fat Diet Fed Rats.
From: Department of Biochemistry, University of Madras, Guindy campus, Chennai-600 025, India. vijaimohan2000@yahoo.com
Life sciences
- Publish Date: Jun 2006
- ISSN: 0024-3205
- Volume: 79
- Issue: 5
- Pages: 448-54
- Medium: Print
- Language: English
- Citation (JAMA): Vijaimohan K, Jainu Mallika, Sabitha K E, et al. Beneficial Effects of Alpha Linolenic Acid Rich Flaxseed Oil on Growth Performance and Hepatic Cholesterol Metabolism in High Fat Diet Fed Rats.. Life Sci. Jun 2006;79:448-54
Abstract
The purpose of the study was to investigate the effect of flaxseed oil (FO), rich in alpha-linolenic acid (ALA) (18:3 n-3) on growth parameters and lipid metabolism of rats fed with high fat diet. High fat diet (HFD) resulted in significant alterations in hepatic lipids, increase in body weight gain and negative effect on lipoprotein metabolism. FO supplementation significantly lowered the increase in body weight gain, liver weight, plasma cholesterol, triglycerides, phospholipids, free fatty acids, high-density lipoprotein (HDL), low-density lipoprotein-cholesterol (LDL-C), very low-density lipoprotein (VLDL), LDL/HDL and TC/HDL ratio in HFD fed rats. FO significantly reduced the hepatic and plasma lipid levels indicating its hypolipidemic activity. On the other hand, oral administration of FO exhibited lower plasma lipoprotein profile as compared to HFD rats. Hepatic protection by FO is further substantiated by the normal liver histological findings in HFD fed rats. These data suggest that FO participate in the normal regulation of plasma lipid concentration and cholesterol metabolism in liver. No adverse effect of FO on growth parameters and plasma lipids in rats fed with fat-free diet. The results of the present study demonstrate that FO may be developed as a useful therapy for hyperlipidemia through reducing hepatic lipids, thereby proving its hypolipidemic activity.
Mesh Headings (Keywords): Animals, Body Weight, Cholesterol, Dietary Fats, Linseed Oil, Lipoproteins, Liver, Male, Organ Size, Rats, Rats, Wistar, alpha-Linolenic Acid
Check for Full Text / PubMed Unique Identifier (PMID): 16490217
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