Fibrinolytic Risk Factor Clustering and Insulin Resistance in Healthy Male Relatives of Men with Intermittent Claudication.
From: Department of Vascular Surgery, St James’s Hospital, Leeds, UK.
The British journal of surgery
- Publish Date: Mar 2006
- ISSN: 0007-1323
- Volume: 93
- Issue: 3
- Pages: 315-24
- Medium: Print
- Language: English
- Citation (JAMA): Parry D J, Grant P J, Scott D J A, et al. Fibrinolytic Risk Factor Clustering and Insulin Resistance in Healthy Male Relatives of Men with Intermittent Claudication.. Mar 2006;93:315-24
Abstract
BACKGROUND: Raised fibrinolytic factors predict cardiovascular risk in healthy subjects. The aim of this study was to measure fibrinolytic factors and insulin resistance in healthy male first-degree relatives of men with intermittent claudication younger than 65 years. METHODS: The study compared 165 healthy first-degree relatives with 165 age-, sex- and race-matched control subjects free from a personal or family history of premature cardiovascular disease. Primary outcome measures were plasminogen activator inhibitor 1 (PAI-1), tissue plasminogen activator (tPA) and D-dimer levels. Insulin resistance was estimated by Homeostasis Model Assessment. Clinical and biochemical risk factors were measured and subjects genotyped for the PAI-1 4G/5G polymorphism. RESULTS: First-degree relatives had significantly higher mean PAI-1 (10.23 versus 7.85 ng/ml; P = 0.024), tPA (9.98 versus 8.29 ng/ml; P < 0.001) and D-dimer levels (56.6 versus 46.1 ng/ml; P = 0.004). They also had significantly higher insulin resistance (1.85 versus 1.53; P < 0.001) and clustered multiple atherogenic risk factors. On multivariate analysis the association between both tPA and D-dimer levels and relative status was independent of other variables. CONCLUSION: Raised levels of PAI-1, tPA, D-dimer and estimated insulin resistance were present in the healthy male first-degree relatives of men with intermittent claudication. These data support the hypothesis of fibrinolytic risk factor clustering in this high-risk population.
Mesh Headings (Keywords): Cardiovascular Diseases, Cross-Sectional Studies, Fibrin Fibrinogen Degradation Products, Fibrinolysis, Humans, Insulin Resistance, Intermittent Claudication, Male, Middle Aged, Plasminogen Activator Inhibitor 1, Risk Factors, Tissue Plasminogen Activator
Check for Full Text / PubMed Unique Identifier (PMID): 16498597
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