Trpa1 is a Substrate for De-ubiquitination by the Tumor Suppressor Cyld.
From: Laboratory of Cell Biology and Immunology, Center for Biomedical Research at Queen’s Medical Center, Honolulu, HI 96813, USA.
Cellular signalling
- Publish Date: Oct 2006
- ISSN: 0898-6568
- Volume: 18
- Issue: 10
- Pages: 1584-94
- Medium: Print
- Language: English
- Citation (JAMA): Stokes Alexander, Wakano Clay, Koblan-Huberson Murielle, et al. Trpa1 is a Substrate for De-ubiquitination by the Tumor Suppressor Cyld.. Cell. Signal. Oct 2006;18:1584-94
Abstract
Certain TRP cation channels confer the ability to sense environmental stimuli (heat, cold, pressure, osmolarity) across physiological and pathophysiological ranges. TRPA1 is a TRP-related channel that responds to cold temperatures, and pungent compounds that include the cold-mimetic icilin and cannabinoids. The initial report of TRPA1 as a transformation-associated gene product in lung epithelia is at odds with subsequent descriptions of a tissue distribution for TRPA1 that is restricted to sensory neurons. Here, we report that the human TRPA1 protein is widely expressed outside the CNS, and is indeed dys-regulated during oncogenic transformation. We describe that TRPA1 associates with the tumor-suppressor protein CYLD. TRPA1 is a novel substrate for the de-ubiquitinating activity of CYLD, and this de-ubiquitination has the net effect of increasing the cellular pool of TRPA1 proteins. Oncogenic mutations in the CYLD gene may therefore be predicted to alter cellular levels of TRPA1.
Mesh Headings (Keywords): Calcium Channels, Cells, Cultured, Central Nervous System, Gene Expression, Gene Expression Profiling, Humans, Membrane Proteins, Nerve Tissue Proteins, Protein Binding, Substrate Specificity, Tumor Suppressor Proteins, Ubiquitin
Check for Full Text / PubMed Unique Identifier (PMID): 16500080
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.