Arterial Characteristics in Normotensive Offspring of Parents with or Without a History of Hypertension.
From: Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium.
American journal of hypertension : journal of the American Society of Hypertension
- Publish Date: Mar 2006
- ISSN: 0895-7061
- Volume: 19
- Issue: 3
- Pages: 264-9
- Medium: Print
- Language: English
- Citation (JAMA): Kucerová Jitka, Filipovský Jan, Staessen Jan A, et al. Arterial Characteristics in Normotensive Offspring of Parents with or Without a History of Hypertension.. Am. J. Hypertens. Mar 2006;19:264-9
Abstract
BACKGROUND: In this study we compared the arterial characteristics and blood pressure (BP) of normotensive offspring of two normotensive parents (OFF/NT) and normotensive offspring who had at least one hypertensive parent (OFF/HT). METHODS: A total of 174 OFF/HT (17 to 40 years of age) and 59 OFF/NT (16 to 34 years) were recruited in Cracow, Poland (n = 138) and Pilsen, Czech Republic (n = 95). Peripheral pulse pressure (PPp) was determined from conventional and 24-h ambulatory BP. A SphygmoCor device was used to measure the central (CAIx) and peripheral (PAIx) systolic augmentation indexes, central pulse pressure (PPc), and the aortic pulse wave velocity (PWV). In multivariate analyses family clusters and significant covariates were accounted for. RESULTS: The OFF/HT had higher (.14 < P < .0007) conventional BP and PPp on conventional BP measurement (121/75 v 114/71 mm Hg and 46 v 42 mm Hg) as well as on 24-h ambulatory monitoring (118/70 v 114/67 mm Hg and 48 v 47 mm Hg). OFF/HT, compared with OFF/NT, also had higher (.05 < P < .0008) PPc (28 v 26 mm Hg), PAIx (54.7% v 44.9%), CAIx (108.8% v 99.8%), and PWV (7.4 v 6.6 m/sec). However, complex adjustment including mean arterial pressure and age removed the differences between the offspring in the PAIx, CAIx, and PWV. CONCLUSIONS: Large-artery properties are altered in OFF/HT compared with OFF/NT. The findings from this cross-sectional study suggest that the alterations in arterial function in subjects with a family history of hypertension are determined mainly by an increased BP and age-related hemodynamic changes.
Mesh Headings (Keywords): Adolescent, Adult, Adult Children, Arteries, Blood Pressure, Blood Pressure Monitoring, Ambulatory, Cross-Sectional Studies, Female, Humans, Hypertension, Male, Pulse
Check for Full Text / PubMed Unique Identifier (PMID): 16500511
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