Sodium Sensitivity of Arterial Blood Pressure in L-name Hypertensive but Not Enos Knockout Mice.
From: Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. dmattson@mcw.edu
American journal of hypertension : journal of the American Society of Hypertension
- Publish Date: Mar 2006
- ISSN: 0895-7061
- Volume: 19
- Issue: 3
- Pages: 327-9
- Medium: Print
- Language: English
- Citation (JAMA): Mattson David L, Meister Carla J, et al. Sodium Sensitivity of Arterial Blood Pressure in L-name Hypertensive but Not Enos Knockout Mice.. Am. J. Hypertens. Mar 2006;19:327-9
Abstract
The present studies determined the sensitivity of mean arterial pressure (MAP) to sodium intake in endothelial nitric oxide synthase (eNOS) knockout mice, wild-type mice (C56BL/6J), and wild-type mice intravenously administered the nonspecific NOS inhibitor N(G)-nitro-l-arginine methyl ester (L-NAME, 8.6 mg/kg/d). Arterial blood pressure was measured from chronically implanted femoral arterial catheters in conscious, freely moving mice. The MAP was unaltered from the low sodium ( approximately 200 microEq/d) intake level of 106 +/- 3 mm Hg in wild-type mice when sodium intake was increased to approximately 1000 microEq/d (n = 12). Chronic administration of L-NAME to wild-type mice led to a sodium-dependent increase in MAP from 111 +/- 7 mm Hg to 124 +/- 5 mm Hg when the mice were placed on an elevated sodium intake (n = 7). In contrast to the L-NAME-treated mice, MAP was unaltered in eNOS knockout mice (n = 8) when sodium intake was increased (128 +/- 3 mm Hg v 129 +/- 5 mm Hg). These experiments demonstrate that eNOS knockout and L-NAME-treated wild-type mice are hypertensive relative to wild-type controls when sodium intake is elevated, but only L-NAME-treated mice exhibited a sodium-sensitive increase in MAP. Therefore, nitric oxide produced by eNOS does not appear to be important in the physiologic adaptation to elevated sodium chloride intake.
Mesh Headings (Keywords): Animals, Blood Pressure, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, NG-Nitroarginine Methyl Ester, Nitric Oxide Synthase Type III, Sodium Chloride
Check for Full Text / PubMed Unique Identifier (PMID): 16500522
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