Policing the Ball: a New Potassium Channel Subunit Determines Inactivation Rate.
From: Department of Pharmacology and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Neuron
- Publish Date: Mar 2006
- ISSN: 0896-6273
- Volume: 49
- Issue: 5
- Pages: 642-4
- Medium: Print
- Language: English
- Citation (JAMA): Kaczmarek Leonard K, et al. Policing the Ball: a New Potassium Channel Subunit Determines Inactivation Rate.. Neuron Mar 2006;49:642-4
Abstract
Inactivation of potassium currents during maintained firing results in a progressive increase in action potential width and neuronal excitability. In Kv1.1 channels, inactivation has attributed to a beta subunit that blocks the pore of the channel shortly after channel opening. In this issue of Neuron, Shulte and colleagues have identified a novel channel subunit whose interaction with Kv1.1 and the beta subunit prevents such inactivation. Mutations in this subunit lead to temporal lobe epilepsy.
Mesh Headings (Keywords): Animals, Humans, Kv1.2 Potassium Channel, Membrane Potentials, Models, Biological, Neural Inhibition, Protein Subunits
Check for Full Text / PubMed Unique Identifier (PMID): 16504937
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