Sleep Duration As a Risk Factor for the Development of Type 2 Diabetes.
From: Yale University School of Medicine, 300 Cedar Street, TAC 441, P.O. Box 208057, New Haven, CT 06520-8057, USA. henry.yaggi@yale.edu
Diabetes care
- Publish Date: Mar 2006
- ISSN: 0149-5992
- Volume: 29
- Issue: 3
- Pages: 657-61
- Medium: Print
- Language: English
- Citation (JAMA): Yaggi H Klar, Araujo Andre B, McKinlay John B, et al. Sleep Duration As a Risk Factor for the Development of Type 2 Diabetes.. Diabetes Care Mar 2006;29:657-61
Abstract
OBJECTIVE: Short-term partial sleep restriction results in glucose intolerance and insulin resistance. The purpose of this study was to assess the long-term relationship between sleep duration and the incidence of clinical diabetes. RESEARCH DESIGN AND METHODS: A cohort of men from the Massachusetts Male Aging Study without diabetes at baseline (1987-1989) were followed until 2004 for the development of diabetes. Average number of hours of sleep per night was grouped into the following categories: < or =5, 6, 7, 8, and >8 h. Incidence rates and relative risks (RRs) were calculated for the development of diabetes in each sleep duration category. Those reporting 7 h of sleep per night served as the reference group. Multivariate analysis was performed using Poisson regression. RESULTS: Men reporting short sleep duration (< or =5 and 6 h of sleep per night) were twice as likely to develop diabetes, and men reporting long sleep duration (>8 h of sleep per night) were more than three times as likely to develop diabetes over the period of follow-up. Elevated risks remained essentially unchanged after adjustment for age, hypertension, smoking status, self-rated health status, education, and waist circumference (RR 1.95 [95% CI 0.95-4.01] for < or =5 h and 3.12 [1.53-6.37] for >8 h). RRs were altered considerably for the two extreme sleep groups when adjusted for testosterone (1.51 [0.71-3.19] for < or =5 h and 2.81 [1.34-5.90] for >8 h), suggesting that the effects of sleep on diabetes could be mediated via changes in endogenous testosterone levels. CONCLUSIONS: Short and long sleep durations increase the risk of developing diabetes, independent of confounding factors. Sleep duration may represent a novel risk factor for diabetes.
Mesh Headings (Keywords): Aged, Diabetes Mellitus, Type 2, Health Surveys, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Sleep, Sleep Disorders, Time Factors
Check for Full Text / PubMed Unique Identifier (PMID): 16505522
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