Similar Protein Phosphatases Control Starch Metabolism in Plants and Glycogen Metabolism in Mammals.
From: Department of Metabolic Biology, John Innes Centre, Norwich NR4 7UH, United Kingdom.
The Journal of biological chemistry
- Publish Date: Apr 2006
- ISSN: 0021-9258
- Volume: 281
- Issue: 17
- Pages: 11815-8
- Medium: Print
- Language: English
- Citation (JAMA): Niittylä Totte, Comparot-Moss Sylviane, Lue Wei-Ling, et al. Similar Protein Phosphatases Control Starch Metabolism in Plants and Glycogen Metabolism in Mammals.. J. Biol. Chem. Apr 2006;281:11815-8
Abstract
We report that protein phosphorylation is involved in the control of starch metabolism in Arabidopsis leaves at night. sex4 (starch excess 4) mutants, which have strongly reduced rates of starch metabolism, lack a protein predicted to be a dual specificity protein phosphatase. We have shown that this protein is chloroplastic and can bind to glucans and have presented evidence that it acts to regulate the initial steps of starch degradation at the granule surface. Remarkably, the most closely related protein to SEX4 outside the plant kingdom is laforin, a glucan-binding protein phosphatase required for the metabolism of the mammalian storage carbohydrate glycogen and implicated in a severe form of epilepsy (Lafora disease) in humans.
Mesh Headings (Keywords): Animals, Arabidopsis, Arabidopsis Proteins, Chloroplasts, Glucans, Glycogen, Humans, Mammals, Phosphoprotein Phosphatases, Phosphorylation, Plant Leaves, Starch
Check for Full Text / PubMed Unique Identifier (PMID): 16513634
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.