A Novel Spermatogenesis-specific Upar Gene Expressed in Human and Mouse Testis.
From: School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200240, China.
Biochemical and biophysical research communications
- Publish Date: Apr 2006
- ISSN: 0006-291X
- Volume: 342
- Issue: 4
- Pages: 1223-7
- Medium: Print
- Language: English
- Citation (JAMA): Teng Xiaokun, Yang Jun, Xie Yong, et al. A Novel Spermatogenesis-specific Upar Gene Expressed in Human and Mouse Testis.. Biochem. Biophys. Res. Commun. Apr 2006;342:1223-7
Abstract
The urokinase receptor, uPAR, which binds to the urinary-type plasminogen activator, controls matrix degradation in the processes of tissue remodeling, cell migration, and invasion. In the present study, we found a new urokinase receptor gene that encodes a 249-amino acid putative protein. Northern blot analysis showed specific expression in the testis of this gene, which we named the spermatogenesis-related gene (SGRG). In situ hybridization revealed a strong expression signal for SGRG in spermatogonia, but not in spermatocytes. Therefore, we conjecture that SGRG may regulate spermatocyte migration through breakdown of extracellular matrix protein barriers in spermatogenesis. Since SGRG is specifically expressed in spermatogonia, it provides an attractive candidate for development of a contraceptive vaccine.
Mesh Headings (Keywords): Amino Acid Sequence, Animals, Conserved Sequence, Gene Expression Profiling, Humans, Male, Mice, Molecular Sequence Data, Receptors, Cell Surface, Sequence Homology, Amino Acid, Species Specificity, Spermatogenesis, Testis
Check for Full Text / PubMed Unique Identifier (PMID): 16516155
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