Chronic Food Restriction and Dopamine Transporter Function in Rat Striatum.
From: Department of Psychiatry, Millhauser Labs, New York University, New York, NY 10016, USA.
Brain research
- Publish Date: Apr 2006
- ISSN: 0006-8993
- Volume: 1082
- Issue: 1
- Pages: 98-101
- Medium: Print
- Language: English
- Citation (JAMA): Zhen Juan, Reith Maarten E A, Carr Kenneth D, et al. Chronic Food Restriction and Dopamine Transporter Function in Rat Striatum.. Brain Res. Apr 2006;1082:98-101
Abstract
The present communication reports on DA uptake in rat striatum in a model of chronic food restriction. The K(m) for DA uptake was unaltered, but the V(max) was reduced by 32%, not supporting the idea that the enhanced behavioral sensitivity to cocaine or d-amphetamine upon chronic food restriction is due to a greater density of DAT at the plasma membrane for drug interaction. Chronic food restriction did not alter the potency of cocaine or D-amphetamine in inhibiting DA uptake in the striatum, suggesting that the enhanced behavioral sensitivity to these drugs upon chronic food restriction is not due to their enhanced affinity for DAT. These results point to factors other than DAT density or affinity underlying the sensitized response to psychostimulants in food restriction.
Mesh Headings (Keywords): Animals, Corpus Striatum, Dopamine, Dopamine Plasma Membrane Transport Proteins, Food Deprivation, Male, Rats, Rats, Sprague-Dawley, Tritium
Check for Full Text / PubMed Unique Identifier (PMID): 16516172
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