Osteopontin is a Novel Marker of Pancreatic Ductal Tissues and of Undifferentiated Pancreatic Precursors in Mice.
From: Department of Genetics & Tumor Cell Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105, USA.
Developmental dynamics : an official publication of the American Association of Anatomists
- Publish Date: Jun 2006
- ISSN: 1058-8388
- Volume: 235
- Issue: 6
- Pages: 1659-67
- Medium: Print
- Language: English
- Citation (JAMA): Kilic Gamze, Wang Junfeng, Sosa-Pineda Beatriz, et al. Osteopontin is a Novel Marker of Pancreatic Ductal Tissues and of Undifferentiated Pancreatic Precursors in Mice.. Dev. Dyn. Jun 2006;235:1659-67
Abstract
Matricellular proteins mediate both tissue morphogenesis and tissue homeostasis in important ways because they modulate cell-matrix and cell-cell interactions. In this study, we found that the matricellular protein osteopontin (Opn) is a novel marker of undifferentiated pancreatic precursors and pancreatic ductal tissues in mice. Our analysis also underscored a specific, dynamic profile of Opn expression in embryonic pancreatic tissues that suggests the participation of this protein’s function in processes involving cell migration, cell-cell interactions, or both. Surprisingly, our analysis of Opn-deficient pancreata did not reveal obvious alterations in the morphology or differentiation of these tissues. Therefore, in embryonic pancreatic tissues, it is possible that other proteins act redundantly to Opn or that this protein’s function is dispensable for pancreas development. Finally, the maintenance of Opn expression in pancreatic tissues of adults argues for a possible function of this protein in injury and pathologic responses.
Mesh Headings (Keywords): Animals, Biological Markers, Mice, Mice, Inbred C57BL, Osteopontin, Pancreatic Ducts, Stem Cells
Check for Full Text / PubMed Unique Identifier (PMID): 16518820
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