Plasma Glucose-lowering Action of Hon-chi in Streptozotocin-induced Diabetic Rats.
From: Department of Food Science, National Pingtung University of Science and Technology, Pingtung City.
Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et métabolisme
- Publish Date: Feb 2006
- ISSN: 0018-5043
- Volume: 38
- Issue: 2
- Pages: 76-81
- Medium: Print
- Language: English
- Citation (JAMA): Chang J-C, Wu M C, Liu I-M, et al. Plasma Glucose-lowering Action of Hon-chi in Streptozotocin-induced Diabetic Rats.. Horm. Metab. Res. Feb 2006;38:76-81
Abstract
Hon-Chi was used for anti-hyperglycemic activity screening in streptozotocin-induced diabetic rats (STZ-diabetic rats) in an attempt to develop new substances for handling diabetes. Mandarin Hon-Chi is red yeast rice fermented with Monascus pilous and Monascus purpureus. Single oral administration of Hon-Chi decreased plasma glucose in STZ-diabetic rats in a dose-dependent manner from 50 mg/kg to 350 mg/kg. Similar treatment with Hon-Chi also lowered the plasma glucose in normal rats as effectively as that produced in STZ-diabetic rats. In addition, oral administration of Hon-Chi at the highest dose (350 mg/kg) attenuated the elevation of plasma glucose induced by an intravenous glucose challenge test in normal rats. Moreover, mRNA levels of phosphoenolpyruvate carboxykinase (PEPCK) in liver from STZ-diabetic rats were reversed in a dose-dependent manner by the repeated oral treatment of Hon-Chi three times daily for two weeks. Otherwise, hyperphagia in STZ-diabetic rats was markedly reversed by similar repeated treatment of Hon-Chi. The obtained results suggest that oral administration of Hon-Chi could decrease hepatic gluconeogenesis to lower plasma glucose in diabetic rats lacking insulin.
Mesh Headings (Keywords): Administration, Oral, Animals, Blood Glucose, Carboxy-Lyases, Complex Mixtures, Diabetes Mellitus, Experimental, Dose-Response Relationship, Drug, Gluconeogenesis, Glucose, Glucose Tolerance Test, Hyperglycemia, Liver, Male, Medicine, Chinese Traditional, Monascus, Rats, Rats, Wistar
Check for Full Text / PubMed Unique Identifier (PMID): 16523406
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