• Johnson P A
• Giles J R

Poultry science

• Publish Date: Feb 2006
• ISSN: 0032-5791
• Volume: 85
• Issue: 2
• Pages: 246-50
• Medium: Print
• Language: English
• Citation (JAMA): Johnson P A, Giles J R, et al. Use of Genetic Strains of Chickens in Studies of Ovarian Cancer.. Poult. Sci. Feb 2006;85:246-50

Abstract

Ovarian cancer is a deadly disease often diagnosed late in development when there is little chance for a successful recovery. Although ovarian cancer is a rare occurrence in most animals, the domestic hen has been shown to spontaneously develop the disease with an age-related incidence. Two strains of hens derived from a similar genetic background and maintained at Cornell University have been shown to differ in the incidence of the disease. At 2 yr of age, the C strain hens have a greater incidence of ovarian neoplasms than do K strain hens. Interestingly, levels of plasma estradiol are elevated in the C strain compared with K strain hens. In addition, plasma immunoreactive inhibin is lower in the C strain than in the K strain. Finally, mRNA expression of the alpha-subunit of inhibin in the granulosa cell layer of the large yellow follicles is lower in the C strain compared with the K strain hens. Further studies using these as well as other strains of hens may be useful in learning more about the etiology of this disease.

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