Novel Delivery System Based on Complexation Hydrogels As Delivery Vehicles for Insulin-transferrin Conjugates.
From: Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA.
Biomaterials
- Publish Date: Jul 2006
- ISSN: 0142-9612
- Volume: 27
- Issue: 20
- Pages: 3846-54
- Medium: Print
- Language: English
- Citation (JAMA): Kavimandan Nikhil J, Losi Elena, Peppas Nicholas A, et al. Novel Delivery System Based on Complexation Hydrogels As Delivery Vehicles for Insulin-transferrin Conjugates.. Biomaterials Jul 2006;27:3846-54
Abstract
A variety of approaches have been investigated to address the problems associated with oral insulin delivery, but the bioavailability of oral insulin is still low. Insulin is rapidly degraded by the enzymes in the GI tract and is not transported across the epithelial barrier easily. The oral insulin formulation developed in this work makes use of complexation hydrogels for oral delivery of insulin bioconjugates. The insulin bioconjugates synthesized in this work consist of insulin bound to transferrin molecule which can be uptaken by the epithelial cells. The conjugates can increase the permeability of insulin across the epithelial barrier by receptor-mediated transcytosis. The transferrin in the conjugate is also shown to stabilize insulin in the presence of intestinal enzymes. Use of complexation hydrogels for delivery of insulin-transferrin conjugate may greatly increase the bioavailability of oral insulin. This is because, the complexation hydrogels are known to exhibit characteristics that make them ideal candidates for oral protein delivery. They can also inhibit the degradation of insulin in the GI tract. Thus, combination of these two approaches may provide an innovative platform for oral insulin delivery.
Mesh Headings (Keywords): Administration, Oral, Animals, Biocompatible Materials, Biological Transport, Caco-2 Cells, Drug Carriers, Humans, Hydrogels, Insulin, Materials Testing, Particle Size, Polyethylene Glycols, Polymethacrylic Acids, Transferrin
Check for Full Text / PubMed Unique Identifier (PMID): 16529810
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