Triterpenic Compounds from "Orujo" Olive Oil Elicit Vasorelaxation in Aorta from Spontaneously Hypertensive Rats.
From: Instituto de la Grasa (CSIC), Avenida Padre Garcia Tejero 4, 41012 Seville, Spain.
Journal of agricultural and food chemistry
- Publish Date: Mar 2006
- ISSN: 0021-8561
- Volume: 54
- Issue: 6
- Pages: 2096-102
- Medium: Print
- Language: English
- Citation (JAMA): Rodriguez-Rodriguez Rosalia, Perona Javier S, Herrera M Dolores, et al. Triterpenic Compounds from "Orujo" Olive Oil Elicit Vasorelaxation in Aorta from Spontaneously Hypertensive Rats.. J. Agric. Food Chem. Mar 2006;54:2096-102
Abstract
There is currently a considerable amount of interest in the benefits of certain dietary elements, and in particular of olive oil, in endothelial function and thus in hypertension. “Orujo” or pomace olive oil is obtained from the residues of the olive by a novel centrifugation process, and it is a good dietary source of triterpenic compounds such as oleanolic and maslinic acid, erythrodiol, and uvaol. Until now, there was no information available regarding the properties of these triterpenoids on the vasculature of hypertensive animals. However, in this in vitro study, we have analyzed the vasorelaxation induced by these triterpenoids in isolated aorta from spontaneously hypertensive rats (SHR). The triterpenoids tested induced concentration-dependent vasorelaxation, mostly involving nitric oxide (NO). Indeed, the responses were attenuated by removal of the endothelium or following pretreatment with the NO synthase inhibitor L-NAME. Furthermore, the differences that were observed in the potency of relaxation, the selectivity, and the dependence on the endothelium were attributed to structural features of the triterpenoids. In conclusion, triterpenic components in pomace olive oil induce vasorelaxation of the aorta from SHR, and this effect generally involves endothelial NO.
Mesh Headings (Keywords): Animals, Aorta, Endothelium, Vascular, Enzyme Inhibitors, Hypertension, Male, Muscle Relaxation, Muscle, Smooth, Vascular, NG-Nitroarginine Methyl Ester, Nitric Oxide Synthase, Plant Oils, Rats, Rats, Inbred SHR, Triterpenes
Check for Full Text / PubMed Unique Identifier (PMID): 16536581
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