Inner Ear Proteomics: a Fad or Hear to Stay.
From: Department of Otolaryngology, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8115, St. Louis, MO 63110, USA. thalmanni@ent.wustl.edu
Brain research
- Publish Date: May 2006
- ISSN: 0006-8993
- Volume: 1091
- Issue: 1
- Pages: 103-12
- Medium: Print
- Language: English
- Citation (JAMA): Thalmann Isolde, et al. Inner Ear Proteomics: a Fad or Hear to Stay.. Brain Res. May 2006;1091:103-12
Abstract
Proteomics, the large-scale analysis of the structure and function of proteins, as well as of protein-protein interactions, has evolved into a major component of ‘systems analysis’. This requires the integration of information from different sources and at multiple levels, and involves two distinct parameters, (1) high-throughput protein separation, identification, and characterization, and (2) the extension of the obtained analytical data for the determination of the physiological function. The inner ear poses exceptional challenges to the study of proteomics because of its minute size, poor accessibility, association with complex fluid spaces, and diversity of cell types. Various approaches to the study of proteomics of the inner ear are presented, and success stories, noteworthy failures and what lies ahead, will be discussed.
Mesh Headings (Keywords): Animals, Ear, Inner, Hearing, Humans, Proteome, Proteomics
Check for Full Text / PubMed Unique Identifier (PMID): 16540098
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.