Variation in Bacterial Flagellins: from Sequence to Structure.
From: Division of Immunity and Infection, University of Birmingham Medical School, Vincent Drive, Edgbaston, Birmingham, UK, B15 2TT.
Trends in microbiology
- Publish Date: Apr 2006
- ISSN: 0966-842X
- Volume: 14
- Issue: 4
- Pages: 151-5
- Medium: Print
- Language: English
- Citation (JAMA): Beatson Scott A, Minamino Tohru, Pallen Mark J, et al. Variation in Bacterial Flagellins: from Sequence to Structure.. Trends Microbiol. Apr 2006;14:151-5
Abstract
Bacterial motility relies chiefly on the rotation of a molecular propeller, the flagellar filament, which is constructed from the protein flagellin. Here, flagellin sequence conservation and diversity is examined in the light of the recently determined flagellar filament structure. As expected, the surface-exposed domains are not conserved. However, the sequences that mediate filament assembly show remarkable conservation, which indicates that all bacterial flagellins are likely to pack into filaments in a similar manner. Flagellins provide a striking illustration of the twin evolutionary themes of conservation and variability.
Mesh Headings (Keywords): Amino Acid Sequence, Bacteria, Conserved Sequence, Flagella, Flagellin, Models, Molecular, Molecular Sequence Data, Sequence Alignment, Variation (Genetics)
Check for Full Text / PubMed Unique Identifier (PMID): 16540320
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.