Getting the Message Across: a Recent Transporter Structure Shows the Way.
From: Department of Pharmacology and Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
Neuron
- Publish Date: Mar 2006
- ISSN: 0896-6273
- Volume: 49
- Issue: 6
- Pages: 791-6
- Medium: Print
- Language: English
- Citation (JAMA): Henry L Keith, Defelice Louis J, Blakely Randy D, et al. Getting the Message Across: a Recent Transporter Structure Shows the Way.. Neuron Mar 2006;49:791-6
Abstract
Efforts to define the mechanisms governing neurotransmitter uptake and drug action have moved into high gear with the publication of a high-resolution structure of a leucine transporter from Aquifex aeolicus, a bacterial member of the SLC6 transporter family. Solved with the substrate leucine bound, the new structure corroborates extensive biochemical and mutagenesis studies performed with related mammalian neurotransmitter transporters and provides exciting suggestions as to how coupling arises between ions and substrates to permit efficient neurotransmitter clearance.
Mesh Headings (Keywords): Animals, Leucine, Membrane Transport Proteins, Models, Biological, Models, Molecular, Protein Conformation
Check for Full Text / PubMed Unique Identifier (PMID): 16543127
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.