Posttranslational Regulation of Mycobacterium Tuberculosis Extracytoplasmic-function Sigma Factor Sigma L and Roles in Virulence and in Global Regulation of Gene Expression.
From: Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Via Gabelli 63, 35100 Padova, Italy.
Infection and immunity
- Publish Date: Apr 2006
- ISSN: 0019-9567
- Volume: 74
- Issue: 4
- Pages: 2457-61
- Medium: Print
- Language: English
- Citation (JAMA): Dainese Elisa, Rodrigue Sébastien, Delogu Giovanni, et al. Posttranslational Regulation of Mycobacterium Tuberculosis Extracytoplasmic-function Sigma Factor Sigma L and Roles in Virulence and in Global Regulation of Gene Expression.. Infect. Immun. Apr 2006;74:2457-61
Abstract
In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.
Mesh Headings (Keywords): Animals, Base Sequence, Gene Expression Regulation, Bacterial, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Molecular Sequence Data, Mycobacterium tuberculosis, Protein Processing, Post-Translational, Sigma Factor, Tuberculosis, Pulmonary, Virulence Factors
Check for Full Text / PubMed Unique Identifier (PMID): 16552079
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