Mutation of Phosphotransacetylase but Not Isocitrate Lyase Reduces the Virulence of Salmonella Enterica Serovar Typhimurium in Mice.
From: VA Healthcare San Diego, 3350 La Jolla Village Dr., San Diego, CA 92161, USA.
Infection and immunity
- Publish Date: Apr 2006
- ISSN: 0019-9567
- Volume: 74
- Issue: 4
- Pages: 2498-502
- Medium: Print
- Language: English
- Citation (JAMA): Kim Yang Re, Brinsmade Shaun R, Yang Zheng, et al. Mutation of Phosphotransacetylase but Not Isocitrate Lyase Reduces the Virulence of Salmonella Enterica Serovar Typhimurium in Mice.. Infect. Immun. Apr 2006;74:2498-502
Abstract
A phosphotransacetylase (pta) mutant of Salmonella enterica serovar Typhimurium was attenuated in mice but survived normally in macrophages. Complementation of the pta mutation in trans restored virulence. An isocitrate lyase (aceA) mutant was virulent, so the inability to use acetate as a sole carbon source does not explain the phenotype.
Mesh Headings (Keywords): Animals, Bacterial Proteins, Isocitrate Lyase, Mice, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred DBA, Mutation, Phosphate Acetyltransferase, Salmonella Infections, Salmonella typhimurium, Virulence
Check for Full Text / PubMed Unique Identifier (PMID): 16552088
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.