The Homer-1 Protein Ania-3 Interacts with the Plasma Membrane Calcium Pump.
From: Molecular Plasticity Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Biochemical and biophysical research communications
- Publish Date: May 2006
- ISSN: 0006-291X
- Volume: 343
- Issue: 2
- Pages: 630-7
- Medium: Print
- Language: English
- Citation (JAMA): Sgambato-Faure Véronique, Xiong Yuning, Berke Joshua D, et al. The Homer-1 Protein Ania-3 Interacts with the Plasma Membrane Calcium Pump.. Biochem. Biophys. Res. Commun. May 2006;343:630-7
Abstract
The Homer family of scaffold proteins couples NMDA receptors to metabotropic glutamate receptors and links extracellular signals to calcium release from intracellular stores. Ania-3 is a member of the Homer family and is rapidly inducible in brain in response to diverse stimuli. Here, we report the identification of the plasma membrane Ca2+ ATPase (PMCA) as a novel Ania-3/Homer-associated protein. Ania-3/Homer interacts with the b-splice forms of all PMCAs (PMCA1b, 2b, 3b, and 4b) via their PDZ domain-binding COOH-terminal tail. Ectopically expressed Ania-3 colocalized with the PMCA at the plasma membrane of polarized MDCK epithelial cells, and endogenous Ania-3/Homer and PMCA2 are co-expressed in the soma and dendrites of primary rat hippocampal neurons. The interaction between Ania-3/Homer and PMCAs may represent a novel mechanism by which local calcium signaling and hence synaptic function can be modulated in neurons.
Mesh Headings (Keywords): Animals, Binding Sites, Calcium-Transporting ATPases, Carrier Proteins, Cell Membrane, Cells, Cultured, Dogs, Epithelial Cells, Hippocampus, Protein Binding, Rats
Check for Full Text / PubMed Unique Identifier (PMID): 16554037
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