Physical Activity, Insulin Sensitivity, and Hypertension Among Us Adults: Findings from the Insulin Resistance Atherosclerosis Study.
From: Department of Public Health Sciences, School of Medicine, Wake Forest University, Winston-Salem, NC 27104, USA. cfoy@wfubmc.edu
American journal of epidemiology
- Publish Date: May 2006
- ISSN: 0002-9262
- Volume: 163
- Issue: 10
- Pages: 921-8
- Medium: Print
- Language: English
- Citation (JAMA): Foy Capri Gabrielle, Foley Kristie Long, D'Agostino Ralph B, et al. Physical Activity, Insulin Sensitivity, and Hypertension Among Us Adults: Findings from the Insulin Resistance Atherosclerosis Study.. Am. J. Epidemiol. May 2006;163:921-8
Abstract
Although regular physical activity is associated with less hypertension and improved insulin sensitivity, there is debate regarding the role of insulin sensitivity in hypertension. Thus, in this cross-sectional study, the authors investigated whether physical activity and insulin sensitivity were associated with hypertension. The sample consisted of 1,599 persons aged 40-69 years who participated in the Insulin Resistance Atherosclerosis Study. The outcome measure was hypertension as measured by a standard protocol. Energy expended in vigorous physical activity was calculated from a recall interview on past-year physical activity. Descriptive statistics revealed that 590 (37%) participants had prevalent hypertension. In adjusted logistic regression analysis, participants expending >or=150 kcal/day in vigorous physical activity had an odds ratio for hypertension of 0.73 (95% confidence interval (CI): 0.55, 0.98) in comparison with participants who were sedentary. Further adjustment for insulin sensitivity resulted in attenuation of the effect of vigorous physical activity on hypertension (odds ratio = 0.97, 95% CI: 0.71, 1.33), while the effect of insulin sensitivity was significant (odds ratio = 0.33, 95% CI: 0.26, 0.41). These results suggest that longitudinal studies are warranted to determine whether insulin sensitivity is a mediator of the relation between physical activity and hypertension.
Mesh Headings (Keywords): Adult, Aged, Atherosclerosis, Chi-Square Distribution, Cross-Sectional Studies, Female, Humans, Hypertension, Insulin Resistance, Male, Middle Aged, Motor Activity, Prevalence, Prospective Studies, Risk Factors, United States
Check for Full Text / PubMed Unique Identifier (PMID): 16554349
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