Cluster Headache is Associated with the G1246a Polymorphism in the Hypocretin Receptor 2 Gene.
From: Department of Neurology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany. schuerks@hotmail.com
Neurology
- Publish Date: Jun 2006
- ISSN: 1526-632X
- Volume: 66
- Issue: 12
- Pages: 1917-9
- Medium: Internet
- Language: English
- Citation (JAMA): Schürks M, Kurth T, Geissler I, et al. Cluster Headache is Associated with the G1246a Polymorphism in the Hypocretin Receptor 2 Gene.. Neurology Jun 2006;66:1917-9
Abstract
The G1246A polymorphism in the gene of the hypocretin receptor 2 (HCRTR2) has been linked to the risk for cluster headache (CH). The authors examined this association in a large sample of 226 patients with CH and 266 controls from Germany. The genotype and allele distribution varied significantly between patients and controls. Homozygous carriers of the G-allele had a twofold increase in risk for CH (OR 1.97; 95% CI 1.32 to 2.92; p = 0.0007).
Mesh Headings (Keywords): Adult, Cluster Headache, DNA Mutational Analysis, Female, Genetic Predisposition to Disease, Genetic Screening, Germany, Humans, Male, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Prevalence, Receptors, G-Protein-Coupled, Receptors, Neuropeptide, Risk Assessment, Risk Factors, Variation (Genetics)
Check for Full Text / PubMed Unique Identifier (PMID): 16554494
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