Effect of Growth Hormone on Susceptibility to Diet-induced Obesity.
From: School of Human and Consumer Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701, USA. berrymad@ohio.edu
Endocrinology
- Publish Date: Jun 2006
- ISSN: 0013-7227
- Volume: 147
- Issue: 6
- Pages: 2801-8
- Medium: Print
- Language: English
- Citation (JAMA): Berryman Darlene E, List Edward O, Kohn Douglas T, et al. Effect of Growth Hormone on Susceptibility to Diet-induced Obesity.. Endocrinology Jun 2006;147:2801-8
Abstract
Mice with a deficiency in GH function due to disruption of the GH receptor/binding protein gene (GHR(-/-)) are long lived, insulin sensitive, and obese, whereas mice with excess GH function due to expression of a bovine GH transgene (bGH) are short lived, glucose intolerant, and lean. When challenged with a high-fat (HF) diet, we hypothesized that these mice would be differentially susceptible to diet-induced obesity. To test this hypothesis, GHR(-/-), bGH, and littermate control (WT) mice were fed a HF diet (40% kcal) or a nutrient-matched low-fat diet (9% kcal) for 12 wk. On the HF diet, all mice, regardless of genotype, showed a similar percent weight gain and exhibited a significant increase in percent body fat and the mass of epididymal, retroperitoneal, and sc fat pads. For bGH mice, the increase in adipose tissue was relatively small, compared with the WT or GHR(-/-) mice, suggesting some resiliency, although not immunity, to diet-induced obesity. GHR(-/-) mice, which are relatively obese on a low-fat diet, responded to the dietary challenge in a manner similar to WT controls. With HF feeding, all genotypes experienced an increase in insulin levels and depot-dependent effect of adipose tissue. Together, these results further support a role for GH in energy balance regulation and nutrient partitioning. More importantly, because there were genotype-specific effects of diet, these data stress the importance of diet selection and sampling multiple adipose depots in studies with these mouse models.
Mesh Headings (Keywords): Animals, Blood Glucose, Body Composition, Dietary Fats, Eating, Energy Metabolism, Growth Hormone, Insulin, Male, Mice, Mice, Inbred C57BL, Obesity, Organ Size, Receptors, Somatotropin, Weight Gain
Check for Full Text / PubMed Unique Identifier (PMID): 16556764
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.