Evaluation of Buparvaquone (Buta-kel Kela, Belgium) As a Treatment of East Coast Fever in Cattle, in the Peri-urban of Dar Es Salaam City, Tanzania.
From: Animal Disease Research Institute, P.O. Box 9254, Dar Es Salaam Tanzania. herimbwambo@yahoo.com
Veterinary parasitology
- Publish Date: Jun 2006
- ISSN: 0304-4017
- Volume: 139
- Issue: 1-3
- Pages: 67-73
- Medium: Print
- Language: English
- Citation (JAMA): Mbwambo H A, Magwisha H B, Mfinanga J M, et al. Evaluation of Buparvaquone (Buta-kel Kela, Belgium) As a Treatment of East Coast Fever in Cattle, in the Peri-urban of Dar Es Salaam City, Tanzania.. Vet. Parasitol. Jun 2006;139:67-73
Abstract
Evaluation trials of the efficacy of buparvaquone (BUTA-kel KELA Laboratoria, N.V. Belgium), as a treatment of field cases of Theileria parva infection (East Coast fever - ECF) were carried out on 63 cattle in the peri-urban of Dar Es Salaam city, Tanzania, during the period November 2004 to August 2005. Thirty-two cattle (56%) received single-dose treatment (2.5 mg buparvaquone per kg body weight), while two and three-dose treatment with interval(s) of 48 h was given to 33% and 11% of total treated cattle, respectively; 38 cattle (60.3%) were treated at an early stage of the disease, while 25 cattle (39.7%) were treated at an advanced stage of the disease. The rectal body temperature of 90.5% of buparvaquone-treated cattle dropped to normal values (37.5-39.5 degrees C) by day 7 of treatment, and by day 15 of treatment 96.8% of treated cattle showed normal values. Pulmonary signs were observed in 8/68 (11.8%) of total ECF diagnosed cattle and were successfully treated, albeit with parvaquone plus frusemide (Fruvexon); were not included in final evaluation of the efficacy of BUTA-kel. The present evaluation trials record a recovery rate of 95.2%. Buparvaquone (BUTA-kel KELA Laboratoria, N.V. Belgium), therefore, records another efficacious and valuable alternative treatment against East Coast fever in Tanzania.
Mesh Headings (Keywords): Animals, Antiprotozoal Agents, Cattle, Cattle Diseases, Female, Male, Naphthoquinones, Tanzania, Theileria parva, Theileriasis, Treatment Outcome
Check for Full Text / PubMed Unique Identifier (PMID): 16567050
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