Murine Cytomegalovirus Interference with Antigen Presentation Contributes to the Inability of Cd8 T Cells to Control Virus in the Salivary Gland.
From: Department of Molecular Microbiology and Immunology, L220, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA.
Journal of virology
- Publish Date: Apr 2006
- ISSN: 0022-538X
- Volume: 80
- Issue: 8
- Pages: 4200-2
- Medium: Print
- Language: English
- Citation (JAMA): Lu Xiuju, Pinto Amelia K, Kelly Ann M, et al. Murine Cytomegalovirus Interference with Antigen Presentation Contributes to the Inability of Cd8 T Cells to Control Virus in the Salivary Gland.. J. Virol. Apr 2006;80:4200-2
Abstract
Compared to other organs, murine cytomegalovirus (MCMV) replication in the salivary gland is uniquely resistant to CD8 T-cell control. The contribution of viral genes that interfere with antigen presentation (VIPRs) to this resistance was assessed using a mutant lacking MCMV’s known VIPRs. Salivary gland titers of the VIPR-deficient virus were at least 10-fold lower than those of the wild type during the persistent phase of infection; the defect was reversed by depleting CD8 T cells. Thus, VIPRs contribute to CD8 T cells’ inability to control virus in the salivary gland.
Mesh Headings (Keywords): Animals, Antigen Presentation, CD8-Positive T-Lymphocytes, Mice, Mice, Inbred BALB C, Muromegalovirus, Salivary Glands
Check for Full Text / PubMed Unique Identifier (PMID): 16571839
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.