Multiple Functions of Notch Signaling in Self-renewing Organs and Cancer.
From: Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland.
FEBS letters
- Publish Date: May 2006
- ISSN: 0014-5793
- Volume: 580
- Issue: 12
- Pages: 2860-8
- Medium: Print
- Language: English
- Citation (JAMA): Wilson Anne, Radtke Freddy, et al. Multiple Functions of Notch Signaling in Self-renewing Organs and Cancer.. FEBS Lett. May 2006;580:2860-8
Abstract
In recent years a substantial body of evidence has accumulated to support the notion that signaling pathways known to be important during embryonic development play important roles in regulating self-renewing tissues. Moreover, the same pathways are often deregulated during tumorigenesis due to mutations of key elements of these pathways. The Notch signaling cascade meets all of the above-mentioned criteria. We discuss here the pleiotropic roles of the Notch signaling pathway in three different self-renewing organs (intestine, hematopoietic system and skin) and how its deregulation is involved in tumorigenesis.
Mesh Headings (Keywords): Animals, Cell Differentiation, Hematopoiesis, Humans, Intestines, Neoplasms, Receptors, Notch, Signal Transduction
Check for Full Text / PubMed Unique Identifier (PMID): 16574107
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