A Noncoding Rna is a Potential Marker of Cell Fate During Mammary Gland Development.
From: Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Proceedings of the National Academy of Sciences of the United States of America
- Publish Date: Apr 2006
- ISSN: 0027-8424
- Volume: 103
- Issue: 15
- Pages: 5781-6
- Medium: Print
- Language: English
- Citation (JAMA): Ginger Melanie R, Shore Amy N, Contreras Alejandro, et al. A Noncoding Rna is a Potential Marker of Cell Fate During Mammary Gland Development.. Proc. Natl. Acad. Sci. U.S.A. Apr 2006;103:5781-6
Abstract
PINC is a large, alternatively spliced, developmentally regulated, noncoding RNA expressed in the regressed terminal ductal lobular unit-like structures of the parous mammary gland. Previous studies have shown that this population of cells possesses not only progenitor-like qualities (the ability to proliferate and repopulate a mammary gland) and the ability to survive developmentally programmed cell death but also the inhibition of carcinogen-induced proliferation. Here we report that PINC expression is temporally and spatially regulated in response to developmental stimuli in vivo and that PINC RNA is localized to distinct foci in either the nucleus or the cytoplasm in a cell-cycle-specific manner. Loss-of-function experiments suggest that PINC performs dual roles in cell survival and regulation of cell-cycle progression, suggesting that PINC may contribute to the developmentally mediated changes previously observed in the terminal ductal lobular unit-like structures of the parous gland. This is one of the first reports describing the functional properties of a large, developmentally regulated, mammalian, noncoding RNA.
Mesh Headings (Keywords): Alternative Splicing, Animals, Female, Lactation, Mammals, Mammary Glands, Animal, Molecular Sequence Data, RNA, Messenger, RNA, Untranslated, Reverse Transcriptase Polymerase Chain Reaction
Check for Full Text / PubMed Unique Identifier (PMID): 16574773
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