Nf-kappab Regulates Spatial Memory Formation and Synaptic Plasticity Through Protein Kinase A/Creb Signaling.
From: Universität Witten/Herdecke, Institut für Neurobiochemie, Stockumer Strasse 10, D-58448 Witten, Germany. c.kaltschmidt@uni-wh.de
Molecular and cellular biology
- Publish Date: Apr 2006
- ISSN: 0270-7306
- Volume: 26
- Issue: 8
- Pages: 2936-46
- Medium: Print
- Language: English
- Citation (JAMA): Kaltschmidt Barbara, Ndiaye Delphine, Korte Martin, et al. Nf-kappab Regulates Spatial Memory Formation and Synaptic Plasticity Through Protein Kinase A/Creb Signaling.. Mol. Cell. Biol. Apr 2006;26:2936-46
Abstract
Synaptic activity-dependent de novo gene transcription is crucial for long-lasting neuronal plasticity and long-term memory. In a forebrain neuronal conditional NF-kappaB-deficient mouse model, we demonstrate here that the transcription factor NF-kappaB regulates spatial memory formation, synaptic transmission, and plasticity. Gene profiling experiments and analysis of regulatory regions identified the alpha catalytic subunit of protein kinase A (PKA), an essential memory regulator, as a new NF-kappaB target gene. Consequently, NF-kappaB inhibition led to a decrease in forskolin-induced CREB phosphorylation. Collectively, these results disclose a novel hierarchical transcriptional network involving NF-kappaB, PKA, and CREB that leads to concerted nuclear transduction of synaptic signals in neurons, accounting for the critical function of NF-kappaB in learning and memory.
Mesh Headings (Keywords): Animals, Cells, Cultured, Cyclic AMP Response Element-Binding Protein, Cyclic AMP-Dependent Protein Kinases, Electrophoretic Mobility Shift Assay, Electrophysiology, Forskolin, Gene Expression Profiling, Hippocampus, Immunohistochemistry, Male, Memory, Mice, Mice, Transgenic, NF-kappa B, Phosphorylation, Synaptic Transmission
Check for Full Text / PubMed Unique Identifier (PMID): 16581769
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.