Cyclin E Overexpression Reduces Infiltrative Growth in Breast Cancer: Yet Another Link Between Proliferation Control and Tumor Invasion.
From: Pathology, Department of Laboratory Medicine, Lund University, Malmö University Hospital, Malmö, Sweden.
Cell cycle (Georgetown, Tex.)
- Publish Date: Mar 2006
- ISSN: 1551-4005
- Volume: 5
- Issue: 6
- Pages: 606-9
- Medium: Internet
- Language: English
- Citation (JAMA): Berglund Pontus, Landberg Göran, et al. Cyclin E Overexpression Reduces Infiltrative Growth in Breast Cancer: Yet Another Link Between Proliferation Control and Tumor Invasion.. Cell Cycle Mar 2006;5:606-9
Abstract
Overexpression of cyclin E is strongly linked to an aggressive phenotype and poor prognosis in breast cancer. Unexpectedly, it has been shown that cyclin E overexpression decreases mobility and invasiveness of breast cancer cells. In fact, in a study of 985 breast cancers, cyclin E correlated with less infiltrative growth. This suggests a novel function for cyclin E in breast cancer tumorigenesis and a mutual control of proliferation and invasive behavior.
Mesh Headings (Keywords): Animals, Breast Neoplasms, Cell Cycle Proteins, Cell Proliferation, Cell Transformation, Neoplastic, Cyclin E, Gene Expression Regulation, Neoplastic, Genes, cdc, Humans, Neoplasm Invasiveness
Check for Full Text / PubMed Unique Identifier (PMID): 16582601
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