C/Ebpalpha: a Tumour Suppressor in Multiple Tissues?
From: Section for Gene Therapy Research, Department of Clinical Biochemistry, Copenhagen University Hospital, Juliane Maries Vej 20-9322, DK2100 Copenhagen, Denmark.
Biochimica et biophysica acta
- Publish Date: Aug 2006
- ISSN: 0006-3002
- Volume: 1766
- Issue: 1
- Pages: 88-103
- Medium: Print
- Language: English
- Citation (JAMA): Schuster Mikkel Bruhn, Porse Bo Torben, et al. C/Ebpalpha: a Tumour Suppressor in Multiple Tissues?. Biochim. Biophys. Acta Aug 2006;1766:88-103
Abstract
The CCATT/enhancer binding protein alpha, C/EBPalpha, is a key transcription factor involved in late differentiation events of several cell types. Besides acting as a classical transcription factor, C/EBPalpha is also a well-characterized inhibitor of mitotic growth in most cell lines tested. In line with its anti-mitotic properties, C/EBPalpha has been shown to interact with, and alter the activities of, several cell cycle related proteins and a number of models as to the mechanistics of C/EBPalpha-mediated growth repression have been proposed. More recently, several reports have indicated that C/EBPalpha acts as a tumour suppressor in the hematopoietic system and that mutation within C/EBPalpha is sufficient to induce tumourigenesis. Here, we will review these data and probe the possibility that C/EBPalpha also act as a tumour suppressor in other C/EBPalpha-expressing tissues.
Mesh Headings (Keywords): Animals, CCAAT-Enhancer-Binding Protein-alpha, Genes, Tumor Suppressor, Humans, Neoplasms, Tissue Distribution
Check for Full Text / PubMed Unique Identifier (PMID): 16616425
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.