Infection with a Periodontal Pathogen Increases Mononuclear Cell Adhesion to Human Aortic Endothelial Cells.
From: Division of Surgical Science, Department of Surgery, College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA.
Atherosclerosis
- Publish Date: Feb 2007
- ISSN: 0021-9150
- Volume: 190
- Issue: 2
- Pages: 271-81
- Medium: Print
- Language: English
- Citation (JAMA): Roth Georg A, Moser Bernhard, Roth-Walter Franziska, et al. Infection with a Periodontal Pathogen Increases Mononuclear Cell Adhesion to Human Aortic Endothelial Cells.. Atherosclerosis Feb 2007;190:271-81
Abstract
BACKGROUND: As a link between periodontal infections and an increased risk for vascular disease has been demonstrated, we assessed the ability of the Gram-negative periodontal pathogen Porphyromonas gingivalis to modulate properties of endothelial cells linked to inflammation and proatherogenic pathways. METHODS AND RESULTS: Primary human aortic endothelial cells (HAEC) were infected with either P. gingivalis strain 381 or its non-invasive fimbriae-deficient mutant, DPG3, and incubated with U-937 monocytes, or Jurkat T cells. P. gingivalis-infected HAEC demonstrated significantly increased adhesion of immune cells compared to non-infected cells or those infected with DPG3. Heat-killed bacteria had no effect on mononuclear cell adhesion and P. gingivalis LPS had only a minimal effect. P. gingivalis infection significantly increased HAEC expression of VCAM-1, ICAM-1 and E-selectin, and enhanced production of IL-6, IL-8 and MCP-1. CONCLUSION: These data demonstrate that live invasive P. gingivalis 381 elicits a pro-atherogenic response in HAEC.
Mesh Headings (Keywords): Aorta, Bacterial Adhesion, Bacteroidaceae Infections, Cell Adhesion, Cells, Cultured, Cytokines, Endothelium, Vascular, Humans, Inflammation, Periodontitis, Porphyromonas gingivalis
Check for Full Text / PubMed Unique Identifier (PMID): 16620832
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