Correlations Between Measures of Insulin Sensitivity and Weight Loss.
From: Mayo Clinic Graduate School of Medicine, Division of Preventive, Occupational and Aerospace Medicine, 200 First St. SW, Rochester, MN 55905, United States. Thompson.Warren@mayo.edu
Diabetes research and clinical practice
- Publish Date: Nov 2006
- ISSN: 0168-8227
- Volume: 74
- Issue: 2
- Pages: 129-34
- Medium: Print
- Language: English
- Citation (JAMA): Thompson Warren G, Slezak Jeffrey M, et al. Correlations Between Measures of Insulin Sensitivity and Weight Loss.. Diabetes Res. Clin. Pract. Nov 2006;74:129-34
Abstract
OBJECTIVE: Many formulas have been proposed to calculate insulin sensitivity and studies have shown their effectiveness. However, few studies have been done to compare formulas. METHODS: Seventy-two obese participants completed a randomized weight loss study. Weight loss, change in body fat and change in waist circumference were used as surrogates for change in insulin sensitivity. Correlation coefficients were calculated for each of these surrogates with proposed formulas for insulin sensitivity found in the literature. RESULTS: The change in insulin sensitivity using the formula proposed by McAuley (exp(2.63-0.28 x ln(fasting insulin)-0.31 x ln(fasting triglyceride in mmol/l)) showed the greatest correlation with weight loss (r=-0.59, p<0.0001) and was statistically superior to change in fasting glucose, fasting insulin and homeostasis model assessment (HOMA). CONCLUSIONS: The insulin sensitivity formula proposed by McAuley provides an accurate means of detecting insulin resistance. As it does not require a glucose tolerance test, it is also easier and less expensive than most other formulas. Use of this formula rather than fasting glucose would detect many more patients with insulin resistance who are at risk for subsequent diabetes and other complications.
Mesh Headings (Keywords): Adipose Tissue, Blood Glucose, Body Mass Index, Body Size, Body Weight, C-Reactive Protein, Humans, Hypoglycemic Agents, Insulin, Insulin Resistance, Leptin, Obesity, Weight Loss
Check for Full Text / PubMed Unique Identifier (PMID): 16624438
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