Reuptake of L-dopa-derived Extracellular Dopamine in the Striatum with Dopaminergic Denervation Via Serotonin Transporters.
From: Department of Neurology, Hirosaki University School of Medicine, Hirosaki, Japan. kankazu@cc.hirosaki-u.ac.jp
Neuroscience letters
- Publish Date: Jul 2006
- ISSN: 0304-3940
- Volume: 402
- Issue: 1-2
- Pages: 62-5
- Medium: Print
- Language: English
- Citation (JAMA): Kannari Kazuya, Shen Huo, Arai Akira, et al. Reuptake of L-dopa-derived Extracellular Dopamine in the Striatum with Dopaminergic Denervation Via Serotonin Transporters.. Neurosci. Lett. Jul 2006;402:62-5
Abstract
The aim of our present study was to determine whether exogenous L-DOPA-derived extracellular dopamine (DA) in the denervated striatum is taken up via serotonin (5-HT) transporters. Rats with dopaminergic denervation by 6-hydroxydopamine were injected with L-DOPA 50 mg/kg (i.p.) and extracellular DA levels in the denervated striatum were measured using in vivo microdialysis technique. During the experiments, fluoxetine, a selective serotonin reuptake inhibitor, was locally perfused into the striatum through the microdialysis probe. Cumulative amounts of L-DOPA-derived extracellular DA during 300 min were increased by fluoxetine dose-dependently (10 microM and 50 microM). These results suggest that reuptake of DA via 5-HT transporters plays an important role in the clearance of L-DOPA-derived DA from the extracellular space when dopaminergic neurons are extensively denervated.
Mesh Headings (Keywords): 3,4-Dihydroxyphenylacetic Acid, Animals, Corpus Striatum, Dopamine, Dopamine Agents, Dose-Response Relationship, Drug, Drug Interactions, Extracellular Fluid, Fluoxetine, Homovanillic Acid, Levodopa, Male, Rats, Rats, Wistar, Serotonin Plasma Membrane Transport Proteins, Serotonin Uptake Inhibitors
Check for Full Text / PubMed Unique Identifier (PMID): 16626862
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