Induction of Hypothalamic Serum- and Glucocorticoid-induced Protein Kinase-1 Gene Expression and Its Relation to Plasma Des-acyl Ghrelin in Energy Homeostasis in Mice.
From: Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Miyagi 980-8575, Japan. knonogaki-tky@umin.ac.jp
Biochemical and biophysical research communications
- Publish Date: Jun 2006
- ISSN: 0006-291X
- Volume: 344
- Issue: 2
- Pages: 696-9
- Medium: Print
- Language: English
- Citation (JAMA): Nonogaki Katsunori, Ohashi-Nozue Kana, Oka Yoshitomo, et al. Induction of Hypothalamic Serum- and Glucocorticoid-induced Protein Kinase-1 Gene Expression and Its Relation to Plasma Des-acyl Ghrelin in Energy Homeostasis in Mice.. Biochem. Biophys. Res. Commun. Jun 2006;344:696-9
Abstract
Serum- and glucocorticoid-induced protein kinase (SGK) is a serine/threonine-specific protein kinase that is transcriptionally regulated by serum, glucocorticoids, and mineral corticoids. Here, we report that fasting or obesity with hyperphagia increased hypothalamic SGK-1 gene expression. Hypothalamic SGK-1 mRNA levels were proportional to daily food intake and body weights in C57BL6J mice, KK mice, and KKA(y) mice matched for age. Plasma des-acyl ghrelin, but not active ghrelin, levels were inversely proportional to daily food intake and body weights among these animals. The increases in hypothalamic SGK-1 gene expression in these animals were not accompanied by increases in plasma corticosterone levels. Under conditions of increased energy usage such as fasting, hypothalamic SGK-1 gene expression and plasma des-acyl ghrelin levels were positively correlated while during conditions of increased energy storage, they were negatively correlated. These results suggest that hypothalamic SGK-1 gene is a novel candidate gene involving in energy homeostasis in mice.
Mesh Headings (Keywords): Animals, Energy Metabolism, Gene Expression Regulation, Ghrelin, Homeostasis, Hypothalamus, Immediate-Early Proteins, Mice, Peptide Hormones, Protein-Serine-Threonine Kinases
Check for Full Text / PubMed Unique Identifier (PMID): 16630541
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