Acetic Acid Activates Hepatic Ampk and Reduces Hyperglycemia in Diabetic Kk-a(Y) Mice.
From: Central Research Institute, Mizkan Group Co., Ltd., Aichi 475-8585, Japan.
Biochemical and biophysical research communications
- Publish Date: Jun 2006
- ISSN: 0006-291X
- Volume: 344
- Issue: 2
- Pages: 597-604
- Medium: Print
- Language: English
- Citation (JAMA): Sakakibara Shoji, Yamauchi Toshimasa, Oshima Yoshifumi, et al. Acetic Acid Activates Hepatic Ampk and Reduces Hyperglycemia in Diabetic Kk-a(Y) Mice.. Biochem. Biophys. Res. Commun. Jun 2006;344:597-604
Abstract
Acetic acid (AcOH), which is a short-chain fatty acid, is reported to have some beneficial effects on metabolism. To test the hypothesis that feeding of AcOH exerts beneficial effects on glucose homeostasis in type 2 diabetes, we fed either a standard diet or one containing 0.3% AcOH to KK-A(y) mice for 8 weeks. Fasting plasma glucose and HbA1c levels were lower in mice fed AcOH for 8 weeks than in control mice. AcOH also reduced the expression of genes involved in gluconeogenesis and lipogenesis, which is in part regulated by 5’-AMP-activated protein kinase (AMPK) in the liver. Finally, sodium acetate, in the form of neutralized AcOH, directly activated AMPK and lowered the expression of genes such as for glucose-6-phosphatase and sterol regulatory element binding protein-1 in rat hepatocytes. These results indicate that the hypoglycemic effect of AcOH might be due to activation of AMPK in the liver.
Mesh Headings (Keywords): Acetic Acid, Animals, Diabetes Mellitus, Type 2, Disease Models, Animal, Enzyme Activation, Hyperglycemia, Liver, Male, Mice, Multienzyme Complexes, Protein-Serine-Threonine Kinases, Treatment Outcome
Check for Full Text / PubMed Unique Identifier (PMID): 16630552
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