Serum Amyloid a Protein As a Predictor of Cardiac Rupture in Acute Myocardial Infarction Patients Following Primary Coronary Angioplasty.
From: Department of Cardiovascular Medicine and Course of Medical and Dental Science, Graduate School of Biomedical Science, Nagasaki University, Nagasaki, Japan. snowman-kt@syd.odn.ne.jp
Circulation journal : official journal of the Japanese Circulation Society
- Publish Date: May 2006
- ISSN: 1346-9843
- Volume: 70
- Issue: 5
- Pages: 530-5
- Medium: Print
- Language: English
- Citation (JAMA): Katayama Toshiro, Nakashima Hiroshi, Takagi Chisa, et al. Serum Amyloid a Protein As a Predictor of Cardiac Rupture in Acute Myocardial Infarction Patients Following Primary Coronary Angioplasty.. Circ. J. May 2006;70:530-5
Abstract
BACKGROUND: The predictors of cardiac rupture (CR) in patients with acute myocardial infarction (AMI) treated with successful primary coronary angioplasty have not been identified. METHODS AND RESULTS: Of 433 consecutive AMI subjects who underwent reperfusion by primary coronary angioplasty within 24 h of onset, CR occurred in 11 (2.5%), free wall rupture in 9, and ventricular septal perforation in 2. Rates of females, diabetes mellitus and anterior infarction were higher in the group of CR patients than in the others (p < 0.05). There were no significant differences between the 2 groups in terms of left ventricular (LV) function soon after recanalization, such as LV ejection fraction, regional wall motion, or end-diastolic volume index. Plasma levels of both high-sensitivity C-reactive protein (hsCRP) and serum amyloid-A protein (SAA) were significantly higher in the CR patients than in the others (hsCRP: 6.7 +/- 6.7 mg/dl vs 3.3 +/- 3.8 mg/dl, p = 0.007; SAA: 699 +/- 812 microg/dl vs 208 +/- 273 microg/dl, p < 0.0001). Multivariate analysis identified SAA as an independent predictor of CR (risk ratio: 8.8, 95% confidence interval: 1.7-25.6, p < 0.05). Conclusions In patients with AMI treated with primary coronary angioplasty, inflammation may be closely related to CR, for which SAA is a useful predictor.
Mesh Headings (Keywords): Aged, Aged, 80 and over, Amyloid, Angioplasty, Transluminal, Percutaneous Coronary, Female, Heart Rupture, Humans, Male, Middle Aged, Myocardial Infarction, Odds Ratio, Predictive Value of Tests, Risk Factors, Ventricular Dysfunction, Left
Check for Full Text / PubMed Unique Identifier (PMID): 16636485
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.