Tumor Necrosis Factor-alpha Activates Signal Transduction in Hypothalamus and Modulates the Expression of Pro-inflammatory Proteins and Orexigenic/Anorexigenic Neurotransmitters.
From: Department of Internal Medicine, State University of Campinas, Sao Paulo, Brazil.
Journal of neurochemistry
- Publish Date: Jul 2006
- ISSN: 0022-3042
- Volume: 98
- Issue: 1
- Pages: 203-12
- Medium: Print
- Language: English
- Citation (JAMA): Amaral Maria E, Barbuio Raquel, Milanski Marciane, et al. Tumor Necrosis Factor-alpha Activates Signal Transduction in Hypothalamus and Modulates the Expression of Pro-inflammatory Proteins and Orexigenic/Anorexigenic Neurotransmitters.. J. Neurochem. Jul 2006;98:203-12
Abstract
Tumor necrosis factor-alpha (TNF-alpha) is known to participate in the wastage syndrome that accompanies cancer and severe infectious diseases. More recently, a role for TNF-alpha in the pathogenesis of type 2 diabetes mellitus and obesity has been shown. Much of the regulatory action exerted by TNF-alpha upon the control of energy stores depends on its action on the hypothalamus. In this study, we show that TNF-alpha activates canonical pro-inflammatory signal transduction pathways in the hypothalamus of rats. These signaling events lead to the transcriptional activation of an early responsive gene and to the induction of expression of cytokines and a cytokine responsive protein such as interleukin-1beta, interleukin-6, interleukin-10 and suppressor of cytokine signalling-3, respectively. In addition, TNF-alpha induces the expression of neurotransmitters involved in the control of feeding and thermogenesis. Thus, TNF-alpha may act directly in the hypothalamus inducing a pro-inflammatory response and the modulation of expression of neurotransmitters involved in energy homeostasis.
Mesh Headings (Keywords): Animals, Behavior, Animal, Blotting, Western, Cytokines, Drug Interactions, Eating, Gene Expression Regulation, Genes, Reporter, Hypothalamus, Injections, Intraventricular, Insulin, Male, Neurotransmitter Agents, RNA, Messenger, Rats, Rats, Wistar, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Transfection, Tumor Necrosis Factor-alpha
Check for Full Text / PubMed Unique Identifier (PMID): 16638016
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.