Curcumin Potently Blocks Kv1.4 Potassium Channels.
From: Department of Neuroscience, The Ohio State University, College of Medicine and Public Health, Columbus, OH 43210-1239, USA.
Biochemical and biophysical research communications
- Publish Date: Jun 2006
- ISSN: 0006-291X
- Volume: 344
- Issue: 4
- Pages: 1161-5
- Medium: Print
- Language: English
- Citation (JAMA): Liu Haiyan, Danthi Sanjay J, Enyeart John J, et al. Curcumin Potently Blocks Kv1.4 Potassium Channels.. Biochem. Biophys. Res. Commun. Jun 2006;344:1161-5
Abstract
Curcumin, a major constituent of the spice turmeric, is a nutriceutical compound reported to possess therapeutic properties against a variety of diseases ranging from cancer to cystic fibrosis. In whole-cell patch-clamp experiments on bovine adrenal zona fasciculata (AZF) cells, curcumin reversibly inhibited the Kv1.4K+ current with an IC50 of 4.4 microM and a Hill coefficient of 2.32. Inhibition by curcumin was significantly enhanced by repeated depolarization; however, this agent did not alter the voltage-dependence of steady-state inactivation. Kv1.4 is the first voltage-gated ion channel demonstrated to be inhibited by curcumin. Furthermore, these results identify curcumin as one of the most potent antagonists of these K+ channels identified thus far. It remains to be seen whether any of the therapeutic actions of curcumin might originate with its ability to inhibit Kv1.4 or other voltage-gated K+ channel.
Mesh Headings (Keywords): Adrenal Glands, Animals, Anti-Inflammatory Agents, Non-Steroidal, Antineoplastic Agents, Cattle, Cells, Cultured, Curcumin, Inhibitory Concentration 50, Kv1.4 Potassium Channel, Patch-Clamp Techniques
Check for Full Text / PubMed Unique Identifier (PMID): 16647042
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