Cd25+foxp3+ Regulatory T Cells Facilitate Cd4+ T Cell Clonal Anergy Induction During the Recovery from Lymphopenia.
From: Department of Medicine, Center for Immunology, University of Minnesota Medical School, 312 Church Street SE, Minneapolis, MN 55455, USA.
Journal of immunology (Baltimore, Md. : 1950)
- Publish Date: May 2006
- ISSN: 0022-1767
- Volume: 176
- Issue: 10
- Pages: 5880-9
- Medium: Print
- Language: English
- Citation (JAMA): Vanasek Tracy L, Nandiwada Sarada L, Jenkins Marc K, et al. Cd25+foxp3+ Regulatory T Cells Facilitate Cd4+ T Cell Clonal Anergy Induction During the Recovery from Lymphopenia.. J. Immunol. May 2006;176:5880-9
Abstract
T cell clonal anergy induction in lymphopenic nu/nu mice was found to be ineffective. Exposure to a tolerizing peptide Ag regimen instead induced aggressive CD4(+) cell cycle progression and increased Ag responsiveness (priming). Reconstitution of T cell-deficient mice by an adoptive transfer of mature peripheral lymphocytes was accompanied by the development of a CD25(+)Foxp3(+)CTLA-4(+)CD4(+) regulatory T cell population that acted to dampen Ag-driven cell cycle progression and facilitate the induction of clonal anergy in nearby responder CD25(-)CD4(+) T cells. Thus, an early recovery of CD25(+) regulatory T cells following a lymphopenic event can prevent exuberant Ag-stimulated CD4(+) cell cycle progression and promote the development of clonal anergy.
Mesh Headings (Keywords): Adoptive Transfer, Animals, CD4-Positive T-Lymphocytes, Cell Proliferation, Cells, Cultured, Clonal Anergy, Forkhead Transcription Factors, Lymphopenia, Mice, Mice, Transgenic, Receptors, Interleukin-2, T-Lymphocytes, Regulatory
Check for Full Text / PubMed Unique Identifier (PMID): 16670295
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.