The Logic of Tgfbeta Signaling.
From: Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, P.O. Box 116, 1275 York Avenue, New York, NY 10021, USA. j-massague@ski.mskcc.org
FEBS letters
- Publish Date: May 2006
- ISSN: 0014-5793
- Volume: 580
- Issue: 12
- Pages: 2811-20
- Medium: Print
- Language: English
- Citation (JAMA): Massagué Joan, Gomis Roger R, et al. The Logic of Tgfbeta Signaling.. FEBS Lett. May 2006;580:2811-20
Abstract
The identification of the TGFbeta cytokine signaling pathway, including membrane receptor serine/threonine kinases and Smad transcription factors as their substrates, has allowed the delineation of a process for conversion of these signals into programs of gene activation and repression that underlie critical cell fate and developmental decisions. The deconstruction of one of these responses - the cell cycle arrest response - into its elemental molecular parts has shed light into the mechanisms used by tumors to evade surveillance and cause metastasis.
Mesh Headings (Keywords): Animals, Humans, Signal Transduction, Transcription, Genetic, Transforming Growth Factor beta
Check for Full Text / PubMed Unique Identifier (PMID): 16678165
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