Role of Adhesion Molecules in the Induction of Restenosis After Angioplasty in the Lower Limb.
From: Department of Vascular Surgery, Rechts der Isar Medical Center, Technical University of Munich, Munich, Germany. heiderpeter@t-online.de
Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter
- Publish Date: May 2006
- ISSN: 0741-5214
- Volume: 43
- Issue: 5
- Pages: 969-77; discussion 977
- Medium: Print
- Language: English
- Citation (JAMA): Heider Peter, Wildgruber Moritz Georg, Weiss Wolfgang, et al. Role of Adhesion Molecules in the Induction of Restenosis After Angioplasty in the Lower Limb.. J. Vasc. Surg. May 2006;43:969-77; discussion 977
Abstract
OBJECTIVE: The adhesion molecules P selectin, E selectin, intercellular adhesion molecule, vascular cellular adhesion molecule (VCAM), and monocyte chemoattractant protein 1 play a important role in the development of arteriosclerotic lesions and are considered main contributors to restenosis after angioplasty. We expected that the serum levels of these markers would increase in the early phase of the first few weeks after angioplasty. METHODS: We assessed prospectively the levels of soluble forms of adhesion molecules on the day before and then 24 hours and 2 and 4 weeks after angioplasty in arteries of the lower limb by using enzyme-linked immunosorbent assays. We investigated the distribution pattern of these markers in 44 patients (25 male and 19 female; age, 67.7 +/- 8.5 years [mean +/- SD]) presenting with intermittent claudication (Fontaine stage IIb). Twelve patients (27.3%) underwent diagnostic angiography, 32 (72.2%) received interventional treatment, 22 (68.8%) received balloon angioplasty, and 10 (31.2%) required stent placement. RESULTS: Ten (31.3%) of the treated patients developed restenosis within 6 months. These patients had significantly higher levels of P selectin (P = .034), E selectin (P = .006), and VCAM (P = .050) at all time points. E selectin, VCAM, and monocyte chemoattractant protein 1 levels increased between 24 hours and 4 weeks after angiographic procedures, thus indicating that the angiographic procedure itself leads to activation and inflammation of the endothelium. CONCLUSIONS: This study emphasizes a meaningful role of the adhesion molecules E selectin, P selectin, and VCAM as interesting contributors to restenosis formation after percutaneous transluminal angioplasty.
Mesh Headings (Keywords): Aged, Angiography, Angioplasty, Balloon, Arterial Occlusive Diseases, Arteriosclerosis, Cell Adhesion Molecules, Chemokine CCL2, E-Selectin, Endothelium, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Intercellular Adhesion Molecule-1, Intermittent Claudication, Ischemia, Leg, Male, Middle Aged, P-Selectin, Postoperative Complications, Recurrence, Risk Factors, Stents, Vascular Cell Adhesion Molecule-1
Check for Full Text / PubMed Unique Identifier (PMID): 16678691
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.