Anti-hepatitis Delta Virus Seroprevalence and Risk Factors in Patients with Hepatitis B in Southeast Turkey.
From: Dicle Universitesi Hastanesi, Klinik Mikrobiyoloji ve Enfeksiyon Hastaliklari Anabilim Dali, 21280, Diyarbakir, Turkey. mkcelen@hotmail.com
Saudi medical journal
- Publish Date: May 2006
- ISSN: 0379-5284
- Volume: 27
- Issue: 5
- Pages: 617-20
- Medium: Print
- Language: English
- Citation (JAMA): Celen Mustafa K, Ayaz Celal, Hosoglu Salih, et al. Anti-hepatitis Delta Virus Seroprevalence and Risk Factors in Patients with Hepatitis B in Southeast Turkey.. May 2006;27:617-20
Abstract
OBJECTIVE: To obtain regional epidemiological data on hepatitis delta virus (HDV, a defective virus) infections, the incidence of anti-HDV positivity and the associated risk factors in asymptomatic hepatitis B virus surface antigen (HBsAg) carriers and in patients with chronic active hepatitis B. METHODS: The study took place at Dicle University Hospital (Diyarbakir, Southeast of Turkey) between January 2002 and July 2004. Anti-HDV screening was performed in asymptomatic hepatitis B carriers (N=889) and in patients with chronic active hepatitis B infection (N=120). We explored the association between anti-HDV positivity and asymptomatic hepatitis B carrier status, presence of active hepatitis B, age, gender, the durations of HBsAg positivity and hepatitis B e antigen (HBeAg) positivity. RESULTS: In 6% of asymptomatic hepatitis B carriers (53/889) and in 27.5% of patients with chronic active hepatitis B (33/120) anti-HDV was positive. The incidence of anti-HDV positivity was significantly higher in patients with chronic active hepatitis B compared with asymptomatic carriers (p<0.001). A significant association between the duration of HBsAg carrier status (3.2 +/- 1.4 years) and anti-HDV positivity was also found (p<0.001). Age, gender, and HBeAg positivity were not significantly associated with anti-HDV positivity (p>0.05). CONCLUSION: Anti-HDV positivity was significantly more common in patients with chronic hepatitis B compared with asymptomatic hepatitis B virus (HBV) carriers in a region with a high prevalence of HBV infection. We found a significant relationship between the duration of HBsAg carrier status and anti-HDV positively, however, age, gender, and presence of HBeAg were not significantly associated with the development of anti-HDV positivity.
Mesh Headings (Keywords): Adult, Antibodies, Viral, Carrier State, Female, Hepatitis B, Hepatitis B Surface Antigens, Hepatitis B e Antigens, Hepatitis D, Hepatitis Delta Virus, Hepatitis delta Antigens, Hospitals, Teaching, Humans, Male, Risk Factors, Seroepidemiologic Studies, Turkey
Check for Full Text / PubMed Unique Identifier (PMID): 16680248
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