Increase of Cd4(+)cd25(+) T Cells in Smad3(-/-) Mice.
From: Department of Immunology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.
World journal of gastroenterology : WJG
- Publish Date: Apr 2006
- ISSN: 1007-9327
- Volume: 12
- Issue: 15
- Pages: 2455-8
- Medium: Print
- Language: English
- Citation (JAMA): Wang Zi-Bing, Cui Yu-Fang, Liu Yu-Qing, et al. Increase of Cd4(+)cd25(+) T Cells in Smad3(-/-) Mice.. World J. Gastroenterol. Apr 2006;12:2455-8
Abstract
AIM: To investigate the changes of lymphocyte subpopulations, especially CD4(+)CD25(+) T regulatory cells in Smad3(-/-) mice. METHODS: Hematological changes and changes of lymphocyte subpopulations were detected in Smad3(-/-) mice using cell counter and flow cytometry, respectively, and compared to their littermate controls. RESULTS: The numbers of neutrophils and lymphocytes in peripheral blood were significantly increased in Smad3(-/-) mice compared to littermate controls. CD19(+) expressing cells in blood and spleen, and CD8(+) T cells in thymus were all markedly decreased in Smad3(-/-) mice. More important, Smad3(-/-) mice had an increased population of CD4(+)CD25(+) T cells in peripheral lymphoid tissues, including thymus, spleen, and lymph nodes. CONCLUSION: These observations suggest that the changes of lymphocyte subpopulations might play a role in susceptibility to inflammation of Smad3(-/-) mice.
Mesh Headings (Keywords): Animals, CD4-Positive T-Lymphocytes, Inflammation, Leukocyte Count, Mice, Mice, Knockout, Neutrophils, Receptors, Interleukin-2, Smad3 Protein, T-Lymphocyte Subsets, Transforming Growth Factor beta
Check for Full Text / PubMed Unique Identifier (PMID): 16688844
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