Mouse Coat Color Mutations: from Fancy Mice to Functional Genomics.
From: Department of Biochemistry and Molecular Biology, University of Iceland, Reykjavik, Iceland. eirikurs@hi.is
Developmental dynamics : an official publication of the American Association of Anatomists
- Publish Date: Sep 2006
- ISSN: 1058-8388
- Volume: 235
- Issue: 9
- Pages: 2401-11
- Medium: Print
- Language: English
- Citation (JAMA): Steingrímsson Eiríkur, Copeland Neal G, Jenkins Nancy A, et al. Mouse Coat Color Mutations: from Fancy Mice to Functional Genomics.. Dev. Dyn. Sep 2006;235:2401-11
Abstract
Mouse coat color mutations have a long history in biomedical research. The viable and visible phenotype of most coat color mutations has made the pigment cell, the melanocyte, an ideal system for genetic, molecular, and cellular analysis. Molecular cloning and analysis of many of the different coat color mutations have revealed the roles of a diverse range of genes, and today we know more about the pathways and proteins that regulate the development and function of pigment cells than we know about most other cell types in mammalian organisms. Coat color mutations have also provided novel insights into stem cell biology and human diseases, including melanoma. In the future, it will be important to build on this history and knowledge by taking advantage of the extensive repertoire of recently developed genome-wide methodologies, available genomic information, and the powerful methods that have been developed for modifying the mouse genome to systematically dissect the development and function of this important cell type. The usefulness of coat color mutations has just begun to emerge.
Mesh Headings (Keywords): Animals, Cell Differentiation, Genomics, Hair Color, Melanocytes, Melanosomes, Mice, Mutation, Pigments, Biological, Skin Pigmentation, Stem Cells
Check for Full Text / PubMed Unique Identifier (PMID): 16691561
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.